Please use this identifier to cite or link to this item: http://ir.lib.seu.ac.lk/handle/123456789/3236
Title: A new b-glucuronidase inhibiting butyrolactone from the marine endophytic fungus Aspergillus terreus
Authors: Haroon, M.H.
Premaratne, S.R.
Choudhry, M. Iqbal
Dharmaratne, H.R.W.
Keywords: Aspergillus terreus
Laurencia ceylanica
Butyrolactone
3-hydroxy- 4-(4-hydroxyphenyl)-5-methoxycarbonyl-5-(4-hydroxy-3-formylbenzyl)-2
5-dihydro-2-furanone
Glucuronidase
Issue Date: 2013
Publisher: Taylor & Francis
Citation: Natural Product Research, 27(12): 1060-1066.
Abstract: An endophytic fungus Aspergillus terreus, var. boedijnii (Blochwitz) was isolated from red marine alga Laurencia ceylanica, J. Agardh, cultured in large scale and extracted with EtOAc. The above-mentioned extract yielded a new butyrolactone, 3-hydroxy-4-(4-hydroxyphenyl)-5-methoxycarbonyl-5-(4-hydroxy-3-formylbenzyl)-2,5-dihydro-2-furanone (1), along with the previously reported nine compounds, butyrolactone-1 (2), 6-hydroxymellin (3), (3 R, 4 R)-6,7-dimethoxy-4-hydroxymellin (4), (+)-territonin (5), (+)-territonin-A (6), (+)-asterrelenin (7), (+)-terrein (8), oleic acid (9) and glucopyranosyl-β-sitosterol (10), on column and preparative thin-layer chromatography. Compounds 1–8 were subjected to β-glucuronidase inhibitory activity test, and 1 showed a remarkable activity, while 2 and 7 showed moderate activity.
URI: https://www.tandfonline.com/doi/abs/10.1080/14786419.2012.708659
Appears in Collections:Research Articles

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