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A new b-glucuronidase inhibiting butyrolactone from the marine endophytic fungus Aspergillus terreus

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dc.contributor.author Haroon, M.H.
dc.contributor.author Premaratne, S.R.
dc.contributor.author Choudhry, M. Iqbal
dc.contributor.author Dharmaratne, H.R.W.
dc.date.accessioned 2018-10-10T06:47:31Z
dc.date.available 2018-10-10T06:47:31Z
dc.date.issued 2013
dc.identifier.citation Natural Product Research, 27(12): 1060-1066. en_US
dc.identifier.uri https://www.tandfonline.com/doi/abs/10.1080/14786419.2012.708659
dc.description.abstract An endophytic fungus Aspergillus terreus, var. boedijnii (Blochwitz) was isolated from red marine alga Laurencia ceylanica, J. Agardh, cultured in large scale and extracted with EtOAc. The above-mentioned extract yielded a new butyrolactone, 3-hydroxy-4-(4-hydroxyphenyl)-5-methoxycarbonyl-5-(4-hydroxy-3-formylbenzyl)-2,5-dihydro-2-furanone (1), along with the previously reported nine compounds, butyrolactone-1 (2), 6-hydroxymellin (3), (3 R, 4 R)-6,7-dimethoxy-4-hydroxymellin (4), (+)-territonin (5), (+)-territonin-A (6), (+)-asterrelenin (7), (+)-terrein (8), oleic acid (9) and glucopyranosyl-β-sitosterol (10), on column and preparative thin-layer chromatography. Compounds 1–8 were subjected to β-glucuronidase inhibitory activity test, and 1 showed a remarkable activity, while 2 and 7 showed moderate activity. en_US
dc.language.iso en_US en_US
dc.publisher Taylor & Francis en_US
dc.subject Aspergillus terreus en_US
dc.subject Laurencia ceylanica en_US
dc.subject Butyrolactone en_US
dc.subject 3-hydroxy- 4-(4-hydroxyphenyl)-5-methoxycarbonyl-5-(4-hydroxy-3-formylbenzyl)-2 en_US
dc.subject 5-dihydro-2-furanone en_US
dc.subject Glucuronidase en_US
dc.title A new b-glucuronidase inhibiting butyrolactone from the marine endophytic fungus Aspergillus terreus en_US
dc.type Article en_US


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