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Antifungal activity of Plectra thus zeylanicus

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dc.contributor.author Mashfiya, HMF
dc.contributor.author Haroon, MH.
dc.date.accessioned 2017-01-05T10:00:35Z
dc.date.available 2017-01-05T10:00:35Z
dc.date.issued 2016-12-29
dc.identifier.citation Proceedings of Fifth Annual Science Research Sessions 2016 on "Enriching the Novel Scientific Research for the Development of the Nation" pp.225-230 en_US
dc.identifier.isbn 9789556271027
dc.identifier.uri http://ir.lib.seu.ac.lk/handle/123456789/2096
dc.description.abstract In a continuation of study towards the discovery of biologically active compounds from Sri Lankan medicinal plants, we have chemically investigated some of the selected plants for their antifungal activity. Preliminary investigations showed that methanol extract of the plant Plectranthuszeylanicus showed significant antifungal activity. The bioactive agent of the above mentioned plant in the most potent fractions with antifungal properties were identified using column chromatography, eluted using gradient elution technique using three different solvents as a mixture of two in different ratios as a combination of hexane: ethyl acetate, ethyl acetate: methanol in increasing polarity, followed by antifungal assay against Aspergillus species for each fractions. Analysis of Antifungal activity profile of the plant showed that the highest inhibition activity in (75% Hexane: 25% Ethyl acetate) and (80% Ethyl acetate: 20% methanol) fractions and the respected value of the highest inhibition diameter was found to be 12.83mm for both fractions. Further isolation of these fractions are under study and introduction of chromatographic techniques into this work will possibly pave the way for an effective discovery of an antifungal agent. The obtained results provide a support for the use of this plant in traditional medicine and it would be a potential antiseptic source for the prevention and treatment of fungal infections. en_US
dc.language.iso en_US en_US
dc.publisher Faculty of Applied Sciences, South Eastern University of Sri lanka en_US
dc.subject Plectrums vulcanizes, en_US
dc.subject column chromatography en_US
dc.subject gradient elation technique en_US
dc.subject anti fungal assay en_US
dc.subject Asperger. en_US
dc.title Antifungal activity of Plectra thus zeylanicus en_US
dc.type Article en_US


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