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Cytotoxicity of Some Sri Lankan Seaweed Extracts

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dc.contributor.author Haroon, M.H.
dc.contributor.author Dharmaratne, H.R.W.
dc.date.accessioned 2017-05-12T03:55:31Z
dc.date.available 2017-05-12T03:55:31Z
dc.date.issued 2012-03-28
dc.identifier.citation Empowering regional development through science and technology,First Annual Science Research Session -2012 en_US
dc.identifier.isbn 9789556270273
dc.identifier.uri http://ir.lib.seu.ac.lk/handle/123456789/2547
dc.description.abstract Algae are known to produce a large number of secondary metabolites with a variety of biological activities. Methanol extracts of 24 seaweeds collected around Sri Lanka were subjected to antibacterial, anti fungal and cytototoxicity studies. Although, none of them were active against the tested bacteria and fungi, some showed cytotoxic activity evidenced the brine shrimp lethality bio assay. Out of the 24 species, nine species (Halimeda discoidea, Sargassum spp., Dictyota spp.-l, Dictyota spp.-2, Amphiroa anceps, Amphiroa fragilissima, Cheilosporum acutilobum, Galaxaura lapidescens, and Tricleocarpa fragilis) showed LC50 value below 1000 gg/ml. Many red algae caused brine shrimp death compared to the brown and green algae tested. Of the eight brown seaweeds, 3 showed LC50 value below 1000 gg/ml, whereas only one of the six green seaweeds tested was effective. The highest activity was recorded in methanol extract of Halimeda discoidea (LC50 0.05 ug ml-I ) compared to the other seaweeds. Further, four species caused brine shrimp death below the level of positive control, 4-hydroxy-2methylquinoline (30.15 Pig ml-I). These preliminary results suggest that the seaweeds could be exploited for the isolation of anti tumor compounds en_US
dc.language.iso en en_US
dc.publisher Faculty of Applied Science,South Eastern University of Sri Lanka en_US
dc.subject Seeweeds en_US
dc.subject Cytotoxicity en_US
dc.subject Antitumor compounds en_US
dc.title Cytotoxicity of Some Sri Lankan Seaweed Extracts en_US
dc.type Article en_US


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