New monoterpenoid by biotransformation of thymoquinone using Aspergillus niger

Yasin Mohammad, Mohammad; Shakya, Ashok; Al-Bakain, Ramia; Haroon, M.H.; Choudhary, M. Iqbal

dc.contributor.author	Yasin Mohammad, Mohammad
dc.contributor.author	Shakya, Ashok
dc.contributor.author	Al-Bakain, Ramia
dc.contributor.author	Haroon, M.H.
dc.contributor.author	Choudhary, M. Iqbal
dc.date.accessioned	2018-10-10T05:25:30Z
dc.date.available	2018-10-10T05:25:30Z
dc.date.issued	2018-06-12
dc.identifier.citation	Bioorganic Chemistry, 80: 212–215.	en_US
dc.identifier.issn	0045-2068
dc.identifier.uri	https://www.sciencedirect.com/science/article/abs/pii/S0045206818303092
dc.description.abstract	Microbial transformation of thymoquinone (5-isopropyl-2-methyl-cyclohexa-2,5-diene-1,4-dione) (1) by suspended cell-cultures of the plant pathogenic fungus Aspergillus niger resulted in the production of three metabolites. These metabolites were identified as 5-isopropyl-2-methyloxepin-1-one (2), 3-hydroxy-5-isopropyl-2- methylcyclohexa-2,5-diene-1,4-dione (3), and 5-isopropyl-2-methylbenzene-1,4-diol (4) by different spectroscopic methods. Metabolite 2 was found to be a new compound. Compound 4 showed a potent antioxidant activity.	en_US
dc.language.iso	en_US	en_US
dc.publisher	Elsevier Publication	en_US
dc.source.uri	https://www.sciencedirect.com/science/article/abs/pii/S0045206818303092
dc.subject	Thymoquinone	en_US
dc.subject	Aspergillus niger	en_US
dc.subject	Fungal transformation	en_US
dc.subject	Oxidation	en_US
dc.subject	Reduction	en_US
dc.subject	Antioxidant activity	en_US
dc.title	New monoterpenoid by biotransformation of thymoquinone using Aspergillus niger	en_US
dc.type	Article	en_US