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Ibuprofen binds DNA: evidenced through fluorescence spectroscopic and molecular docking

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dc.contributor.author Safeena, M. I. S.
dc.date.accessioned 2019-11-26T11:20:44Z
dc.date.available 2019-11-26T11:20:44Z
dc.date.issued 2019-11-27
dc.identifier.citation 9th International Symposium 2019 on “Promoting Multidisciplinary Academic Research and Innovation”. 27th - 28th November 2019. South Eastern University of Sri Lanka, University Park, Oluvil, Sri Lanka. pp. 373-381. en_US
dc.identifier.isbn 978-955-627-189-8
dc.identifier.uri http://ir.lib.seu.ac.lk/handle/123456789/3942
dc.description.abstract Ibuprofen belongs to a class of drugs called non-steroidal anti-inflammatory drugs (NSAIDs) with various pharmacological effects. A set of spectroscopic (in-vitro) and molecular docking (in-silico) studies were accounted to illustrate the binding mode of ibuprofen with calf thymus DNA (ct-DNA), in order to predict its possibility to be a ‘DNA binder’ which is one of the features expected in anticancer and antitumor drug designing. Both the UV-Visible and Fluorescence spectroscopic results denote that, there is a drug-DNA complex formation with binding constants of 1.58 x 105 M-1 and 2 x 10-3 μl ng-1 respectively. These values suggest that ibuprofen having intercalative mode of interaction with ct-DNA. As a confirmation of these results, it was further validated through relative specific viscosity measurements of ct-DNA dug complex. It was revealed an increment while mixing DNA with the drug in ascending order. Molecular docking studies further complemented the experimental results. en_US
dc.language.iso en_US en_US
dc.publisher South Eastern University of Sri Lanka, University Park, Oluvil, Sri Lanka en_US
dc.subject NSAIDs en_US
dc.subject DNA binding en_US
dc.subject Fluorescence spectroscopic en_US
dc.subject Molecular docking en_US
dc.title Ibuprofen binds DNA: evidenced through fluorescence spectroscopic and molecular docking en_US
dc.type Article en_US


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