Synthesis and evaluation of the antimicrobial activity of Schiff base and Succinimide compounds

Abstract

Schiff bases are organic compounds and were first reported by Hugo Schiff in 1864 [1]. These are usually formed by the condensation of primary amines with carbonyl compounds. They have a characteristic group -C=N-, which are called azomethines. The development of the new chemotherapeutic Schiff bases is now attracting the attention of medicinal chemists. It is known to exhibit a variety of powerful activities. Due to the presence of carbon-nitrogen double bond in Schiff bases they have significant biological activities. Such as antibacterial, antifungal [2], antioxidant [3] and anti-inflammatory [3] activities. Succinimides are cyclic imides that have pharmaceutical applications. Due to the presence of both carbonyl and methylene groups, they have high chemical reactivity and biological activity. Succinimides are heterocyclic compounds. In recent years, heterocyclic compounds play an important role in the development of organic synthesis and their wide range of applications in the field of pharmaceuticals, agrochemicals, and veterinary products [4]. The current study has been conducted on synthesis of Schiff bases and Succinimide compounds, to check the purity of all compounds using thin-layer and column chromatography, and to evaluate the antimicrobial activity of each synthesized compound against pathogenic bacteria and fungi.