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Bioactive cyclo-(S-Pro-R-Leu) from Aspergillus flavus, the marine endophytic fungus from brown alga, Dictyota kunthi

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dc.contributor.author Haniffa, H.M.
dc.contributor.author Dharmaratne, H.R.W.
dc.contributor.author Mohammad, M. Yasin
dc.date.accessioned 2022-12-30T09:28:35Z
dc.date.available 2022-12-30T09:28:35Z
dc.date.issued 2022-10-31
dc.identifier.citation Journal of the National Science Foundation of Sri Lanka, 50(3), pp.717–721 en_US
dc.identifier.issn 2362-0161
dc.identifier.uri http://doi.org/10.4038/jnsfsr.v50i3.10805
dc.identifier.uri http://ir.lib.seu.ac.lk/handle/123456789/6391
dc.description.abstract The marine environment is regarded as a rich source of bioactive secondary metabolites, and some of these compounds have been shown to be useful for novel drug discovery. In recent years, research on the chemistry of endophytic fungi from marine algae has shown them to be an important source of secondary metabolites with a wide range of biological activities. The objective of this study was to describe the isolation and identification of bioactive compounds obtained from Aspergillus flavus, hosted in the brown alga, Dictyota kunthi, together with β-glucuronidase bioassay of them. This fungal strain was cultivated on a large scale and extracted with ethyl acetate (EtOAc). Using various column chromatographic and spectroscopic techniques, we isolated and characterized two metabolites, cyclo-(S-Pro-R-Leu), 1 and genistein 2. Cyclo-(S-Pro-R-Leu) inhibited β-glucuronidase with an IC50 value of 83.9 ± 0.1 µM when compared to glucosaccharo-1,4-lactone (IC 50 = 48.4 ± 1.3 µM). This appears to be the first report of the isolation of cyclo-(S-Pro-R-Leu) from this entophyte. To the best of our knowledge, this is the first report of significant β-glucuronidase inhibitory activity of this compound. From these findings, we can confirm that the endophyte from the brown alga, Dictyota kunthi, produces a β-glucuronidase inhibitory metabolite. en_US
dc.language.iso en en_US
dc.publisher National Science Foundation of Sri Lanka en_US
dc.subject β-glucuronidase en_US
dc.subject Aspergillus flavus en_US
dc.subject cyclo- (S-Pro-R-Leu) en_US
dc.subject Dictyota kunthi en_US
dc.subject marine endophytes en_US
dc.title Bioactive cyclo-(S-Pro-R-Leu) from Aspergillus flavus, the marine endophytic fungus from brown alga, Dictyota kunthi en_US
dc.type Article en_US


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