Antibacterial activity of thymoquinone derivative

Mohammad, Mohammad Yasin; Haroon, M. H.; Iqbal Choudhary, M.

dc.contributor.author	Mohammad, Mohammad Yasin
dc.contributor.author	Haroon, M. H.
dc.contributor.author	Iqbal Choudhary, M.
dc.date.accessioned	2023-10-16T05:37:12Z
dc.date.available	2023-10-16T05:37:12Z
dc.date.issued	2023-10-06
dc.identifier.citation	BMC Research Notes 16 (260), 2023, pp. 1-3.	en_US
dc.identifier.issn	1756-0500
dc.identifier.uri	https://doi.org/10.1186/s13104-023-06523-8
dc.identifier.uri	http://ir.lib.seu.ac.lk/handle/123456789/6830
dc.description.abstract	Natural products such as terpenoidal compounds have been extremely tested against pathogenic bacteria. Researches are frequently carried out to find out new natural, semisynthetic and synthetic antibacterial agents due to problems of resistance. Thymoquinone derivative was obtained in our previous study and the current research is a continuation. The antibacterial activity of a monoterpenoid; thymoquinone derivative, 5-isopropyl-2-methyloxepine-1-one (1) has been evaluated for the first time by following the Agar cup bioassay method employed. The bacterial strains used in this study were Escherichia coli and Bacillus subtilis. Compound 1 showed moderate activity against Gram-positive organism; B. subtilis and good activity against Gram-negative species; E. coli with zones of inhibition (ZOI) 10.0 ± 0.2 mm and 11.0 ± 0.2 mm against E. coli and B. subtilis, respectively, and in comparison with antibiotic, imipenem. The zones of inhibition were calculated as the mean of the triplicate. The antibacterial activity of thymoquinone derivative 1 could be explained by the presence of unsaturated lactone.	en_US
dc.language.iso	en_US	en_US
dc.publisher	Springer Nature	en_US
dc.subject	Monoterpenoid	en_US
dc.subject	Pathogenic Bacteria	en_US
dc.subject	Bacillus Subtilis	en_US
dc.subject	Escherichia Coli	en_US
dc.title	Antibacterial activity of thymoquinone derivative	en_US
dc.type	Article	en_US