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Sequence analysis of prion protein gene in bhagnari cattle breed from the hottest region of sibi, balochistan, Pakistan

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dc.contributor.author Rasheed, Rizwana
dc.contributor.author Ahmad, Jamil
dc.contributor.author Hussain, Tanveer
dc.contributor.author Wajid, Abdul
dc.contributor.author Nudhani, Sara
dc.contributor.author Musthafa, Muneeb M.
dc.contributor.author Marikar, Faiz M. M. T.
dc.date.accessioned 2024-01-02T07:42:02Z
dc.date.available 2024-01-02T07:42:02Z
dc.date.issued 2023-10-21
dc.identifier.citation Sequence Analysis of Prion Protein Gene in Bhagnari Cattle Breed from the Hottest Region of Sibi, Balochistan, Pakistan. Ukrainian Journal of Veterinary and Agricultural Sciences, 6(3) pp. 3–7. en_US
dc.identifier.issn 2617-6149
dc.identifier.uri http://ir.lib.seu.ac.lk/handle/123456789/6897
dc.description.abstract Prion diseases are a type of neurodegenerative disorder caused by the transmission of specific pathogens containing prion proteins. Due to the unique structural characteristics of Prion proteins (PrP), which differ from other types of proteins, the extended incubation period observed in the transmission of specific Prions can be attributed to these differences, at least in part. Prions are found in several other mammals and animals. Prions are unique among false protein folding abnormalities because these are infections and contain various strains of contagious agents associated with a unique in vivo phenotype. They can be acquired either by inheritance or sporadically. There are two types: classical and typical BSP. The objective of this study was to observe the Bhagnari cattle breed of Balochistan, Pakistan and compare the PrP gene sequence of the Bhagnari with other reported sequences from Pakistan and other parts of the world. This research collected 40 Bhagnari cattle blood samples from Tali, Bhag Nari, and Sibi district areas. DNA extraction of each sample was performed by inorganic method, and then DNA amplification and sequencing of PRNP Gene was performed. The results of this research work showed different polymorphic variations (SNPs) in 16 samples. In this study, while mutations causing prion diseases in cattle were detected in Italian and German breeds, none were identified in the PRNP gene of the cattle population investigated, despite its association with neurological disorders. en_US
dc.language.iso en_US en_US
dc.publisher National University of Veterinary Medicine and Biotechnology en_US
dc.subject Bhagnari Cattle en_US
dc.subject Prions en_US
dc.subject Polymorphic Variations en_US
dc.subject PRNP Gene en_US
dc.subject Mutations en_US
dc.subject PrP en_US
dc.title Sequence analysis of prion protein gene in bhagnari cattle breed from the hottest region of sibi, balochistan, Pakistan en_US
dc.type Article en_US


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    THESE ARE RESEARCH ARTICLES OF ACADEMIC STAFF, PUBLISHED IN JOURNALS AND PROCEEDINGS ELSWHERE

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