Abstract:
Despite the hostile environment of the stomach, recent studies suggest that gastric
mucosa has a core microbiome. This raises the possibility of a pathogenic role of non
H. pylori organisms in the gastric mucosa which may contribute to dyspeptic
symptoms. Thus, this study investigates bacterial diversity of the stomach using PCR
DGGE techniques to provide information on the possible role of other non-H. pylori
microorganisms in causing gastric pathology. For the first time in Sri Lanka it was
reported the presence of yeast species majority being Candida albicans in the gastric
mucosa and its presence was significantly associated with gastric pathology. A diverse
interpersonal variation of bacteria in the gastric mucosa was observed.
Histopathological grading increased in the presence of low bacterial diversity which
suggest disruption of the normal gastric microbiota with the establishment of
pathogenic microorganisms.
