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Synthesis, characterization and biological activities of 3-nitro isoindoline-1,3-dione analogues

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dc.contributor.author Kamshajini, S.
dc.contributor.author Haroon, M. H.
dc.contributor.author Baheej, M. A.
dc.date.accessioned 2022-12-06T07:51:02Z
dc.date.available 2022-12-06T07:51:02Z
dc.date.issued 2022-11-15
dc.identifier.citation 11th Annual Science Research Sessions 2022 (ASRS-2022) Proceedings on "“Scientific Engagement for Sustainable Futuristic Innovations”. 15th November 2022. Faculty of Applied Sciences, South Eastern University of Sri Lanka, Sammanthurai, Sri Lanka. pp. 15. en_US
dc.identifier.isbn 978-624-5736-60-7
dc.identifier.uri http://ir.lib.seu.ac.lk/handle/123456789/6344
dc.description.abstract N-substituted phthalimides are biologically active chemicals with a broad range of applications. In this present research work, eight 3-Nitroisoindoline-1,3-dione analogues were synthesized and characterized. Furthermore, their antibacterial, antifungal and antioxidant activities were evaluated in vitro. Synthesized compounds were purified using the recrystallization process and the purity was confirmed by thin-layer chromatography. The structures were characterized by FTIR and mass spectroscopic analysis. Using the Disc diffusion method, synthetic 3-Nitroisoindoline-1,3-dione analogues were tested for antibacterial activity against Bacillus spp and Escherichia coli, as well as antifungal activity against Aspergillus spp and Trichoderma spp. Based on the results that compound 2- (CF3 and Cl groups at the 3rd and 4th positions respectively), 3,4-(OCH3 group attached to the 4th position), 7- (CH3 group attached to the 2nd and 3rd position), and showed inhibitory effects against Bacillus spp with the zone of inhibition ranging from 6.66 – 9.83 mm. The compounds 1- (Cl group attached to the 2nd position), 2, and 8- (CF3 group attached to the 4th position) showed inhibitory effects against Escherichia coli with ZOI ranging from 7.83 – 10.66 mm. The compounds 1,3, and 5-(Br group attached to the 4th position) showed inhibitory effects against Aspergillus spp with ZOI ranging from 6.5 – 6.83 mm. The compounds 2, 6- (Cl the group attached to the 4th position), and 8 showed an inhibitory effect against Trichoderma spp with ZOI ranging from 7.5 – 8.0 mm. Synthesized 3-nitro isoindoline1, 3-dione was tested for antioxidant activity by using the DPPH assay. Compound 2 showed moderate antioxidant activity. These 3-nitroisoindoline-1,3- dione analogues could be synthesized and used as antibacterial and antifungal and antioxidant agents. en_US
dc.language.iso en_US en_US
dc.publisher Faculty of Applied Sciences, South Eastern University of Sri Lanka, Sammanthurai. en_US
dc.subject Antibacterial and Antifungal Assay en_US
dc.subject Antioxidant Assay en_US
dc.subject 3-Nitro Isoindoline-1 en_US
dc.subject 3-Dione en_US
dc.title Synthesis, characterization and biological activities of 3-nitro isoindoline-1,3-dione analogues en_US
dc.type Article en_US


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