Please use this identifier to cite or link to this item: http://ir.lib.seu.ac.lk/handle/123456789/6961
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dc.contributor.authorFonseka, D. R. P.-
dc.contributor.authorJayakody, T. C.-
dc.contributor.authorKrishnan, P. S.-
dc.contributor.authorWickramasinghe, N. D.-
dc.contributor.authorAththanayake, A. M. K. C. B.-
dc.contributor.authorWanigasekara, D. N.-
dc.contributor.authorUdara, S.-
dc.date.accessioned2024-03-14T12:04:26Z-
dc.date.available2024-03-14T12:04:26Z-
dc.date.issued2023-12-14-
dc.identifier.citation12th Annual Science Research Sessions 2023 (ASRS-2023) Conference Proceedings of "Exploration Towards Green Tech Horizons”. 14th December 2023. Faculty of Applied Sciences, South Eastern University of Sri Lanka, Sammanthurai, Sri Lanka. pp. 11-12.en_US
dc.identifier.isbn978-955-627-015-0-
dc.identifier.urihttp://ir.lib.seu.ac.lk/handle/123456789/6961-
dc.description.abstractantibiotics, has led to an increasing demand for the exploration of novel antibacterial compounds, particularly those sourced from botanical origins. This study aims to explore the antibacterial potential of phytochemicals obtained from Artocarpus heterophyllus and Mikania micrantha, two indigenous Sri Lankan botanical sources. Synergistic and antagonistic effects were examined by combining A. heterophyllus with a botanical source and a chemical source. This study was conducted to assess the combined effects of these phytochemicals with sodium salt of metatitanic acid (MTA) against certain bacterial strains. The sodium salt of metatitanic acid, a chemical that possesses superior antibacterial properties in previous studies, was used as the chemical source in this study. Additionally, M. micrantha, a plant commonly known as ‘wathupalu’ and utilized in traditional medicinal practices, was used as the botanical source. The A. heterophyllus plant parts (leaves, seeds, stripes and peels) were cleaned, dried and pulverised, and then the aqueous extract was obtained. Similarly, M. micrantha leaves were cleaned, dried and crushed in order to obtain an aqueous extract. The crude extracts were individually assessed for antibacterial activity against Staphylococcus aureus (ATCC 25923) and Pseudomonas aeruginosa (ATCC 27853) using antibiotic sensitivity test (ABST), by well diffusion method employed using Muller-Hinton agar as the growth medium. The plates were incubated for 24 hours at 37°C. The positive control used was Gentamicin and the negative control used was sterile water. The crude extract of A. heterophyllus was combined with M. micrantha extract in 1:1 ratio and was tested against the same species for enhanced antibacterial properties. Similarly, the crude extract of A. heterophyllus was mixed with the sodium salt of MTA and ABST assay was conducted to analyze and compare the antibacterial properties. ANOVA and Post hoc analysis performed using SPSS 27th version revealed that MTA exhibits stronger antibacterial property (23.5±0.4 mm), while the combination of MTA and A. heterophyllus also showed a synergistic effect (24±1.7 mm) against S. aureus. Moreover, the analysis against P. aeruginosa shows that M. micrantha exhibits notable antibacterial properties against this species (27.4±3.6 mm). The statistical significance for all comparisons was established at the p<0.05 level. In conclusion, the sodium salt of MTA, M. micrantha, and their combination with A. heterophyllus exhibit potential antibacterial properties.en_US
dc.language.isoen_USen_US
dc.publisherFaculty of Applied Sciences, South Eastern University of Sri Lanka, Sammanthurai.en_US
dc.subjectArtocarpus Heterophyllusen_US
dc.subjectMikania Micranthaen_US
dc.subjectMetatitanic Aciden_US
dc.subjectAntibacterial Propertiesen_US
dc.titleExploration of antibacterial properties in the combination of Artocarpus heterophyllus with a botanical source and a chemical source: a study on enhanced antimicrobial performancesen_US
dc.typeArticleen_US
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